Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 04:52 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Phase 2b Pivotal Study of Izokibep in Non-infectious, Intermediate-, Posterior- or Pan-uveitis
NCT05384249 · ACELYRIN Inc. · PHASE2 · terminated · last registry update 2025-02-21 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Study primary and secondary endpoints did not achieve statistical significance.” | – | Registry record, ACELYRIN Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against IL17A within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-02-20Results posted on the registry: UCB Biopharma SRL, Bimekizumab (NCT06011733)
- 2026-01-30Results posted on the registry: Novartis Pharmaceuticals, Secukinumab + Placebo (NCT04732117)
- 2025-12-18Results posted on the registry: Novartis Pharmaceuticals, Secukinumab + Placebo (NCT05758415)
- 2025-12-18Also stopped (terminated): Novartis Pharmaceuticals, Secukinumab + Placebo (NCT05758415)
- 2025-12-02Results posted on the registry: Novartis Pharmaceuticals, Secukinumab + Placebo (NCT05722522)
- 2025-12-02Results posted on the registry: Novartis Pharmaceuticals, Secukinumab (NCT05569174)
- 2025-10-21Phase 3 first posted: UCB Biopharma SRL, Bimekizumab + Placebo (NCT07219420)
- 2025-10-16Results posted on the registry: Novartis Pharmaceuticals, Secukinumab + Ustekinumab (NCT04632927)
- 2025-10-15Results posted on the registry: ACELYRIN Inc., Placebo + Izokibep (NCT05905783)
- 2025-10-15Also stopped (terminated): ACELYRIN Inc., Placebo + Izokibep (NCT05905783)
- 2025-08-22Results posted on the registry: Eli Lilly and Company, Ixekizumab (NCT05855967)
- 2025-06-05Results posted on the registry: Eli Lilly and Company, Ixekizumab + Adalimumab (NCT04527380)
- 2025-06-05Results posted on the registry: University of Miami, Secukinumab (NCT04717466)
- 2025-05-23Results posted on the registry: Novartis Pharmaceuticals, Secukinumab (NCT03769168)
- 2025-05-23Results posted on the registry: ACELYRIN Inc., Izokibep + Placebo to izokibep (NCT05623345)
- 2025-05-23Also stopped (terminated): ACELYRIN Inc., Izokibep + Placebo to izokibep (NCT05623345)
- 2025-05-21Phase 3 first posted: Xijing Hospital, Sulodexide + Placebo (NCT06982196)
- 2025-05-20Results posted on the registry: Icahn School of Medicine at Mount Sinai, Ixekizumab (NCT04979910)
- 2025-05-16Also stopped (terminated): Novartis Pharmaceuticals, Secukinumab (NCT05232864)
- 2025-05-16Also stopped (terminated): Novartis Pharmaceuticals, secukinumab + Placebo (NCT04181762)
- 2025-04-25Phase 3 first posted: Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD., Picankibart + Secukinumab (NCT06945107)
- 2025-04-16Results posted on the registry: Novartis Pharmaceuticals, Secukinumab/Adalimumab-Biosimilar (NCT03906136)
- 2025-04-10Phase 3 first posted: UCB Biopharma SRL, Bimekizumab (NCT06921850)
- 2025-04-10Results posted on the registry: UCB Biopharma SRL, bimekizumab (NCT05292131)
- 2025-04-10Results posted on the registry: UCB Biopharma SRL, Bimekizumab (NCT04255862)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision