Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:16 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Disease
NCT05445128 · Ensoma · PHASE2 · terminated · last registry update 2025-07-25 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “This study was voluntarily terminated due to a business decision not to proceed, and not due to any safety issue.” | – | Registry record, Ensoma |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CXCR4 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-12-17Results posted on the registry: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Tbo-filgrastim (NCT03317899)
- 2025-06-22Also stopped (withdrawn): Minovia Therapeutics Ltd., MNV-BM-PLC infusion (NCT04548843)
- 2025-03-21Results posted on the registry: BioLineRx, Ltd., 1.25 mg/kg BL-8040 + BL-8040-matching placebo + 2 mg/kg BL-8040 (NCT05293171)
- 2025-01-07Results posted on the registry: Fred Hutchinson Cancer Center, Anti-Thymocyte Globulin + Cyclophosphamide (NCT01413100)
- 2024-11-06Also stopped (terminated): Ensoma, MGTA-145 + Plerixafor (NCT04762875)
- 2024-10-30Results posted on the registry: X4 Pharmaceuticals, X4P-001 (NCT03005327)
- 2024-10-08Results posted on the registry: Genetix Biotherapeutics Inc., lovo-cel (NCT02140554)
- 2024-09-05Results posted on the registry: BioLineRx, Ltd., BL-8040 + Atezolizumab (NCT03154827)
- 2024-09-05Also stopped (terminated): BioLineRx, Ltd., BL-8040 + Atezolizumab (NCT03154827)
- 2024-08-29Results posted on the registry: Ensoma, MGTA-145 + Plerixafor (NCT04762875)
- 2024-08-14Results posted on the registry: X4 Pharmaceuticals, X4P-001 + axitinib (NCT02667886)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision