Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:10 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study)
NCT05516498 · AstraZeneca · PHASE2 · terminated · last registry update 2026-09-25 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study was ended earlier than planned due to a sponsor decision.” | – | Registry record, AstraZeneca |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against EDNRA within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-09-03Also stopped (terminated): Dr Sudarshan Rajagopal, Macitentan Tablets + Riociguat (NCT05140525)
- 2026-07-06Results posted on the registry: United Therapeutics, Ralinepag + Placebo (NCT04084678)
- 2026-07-06Also stopped (terminated): United Therapeutics, Ralinepag + Placebo (NCT04084678)
- 2026-06-15Also stopped (suspended): City of Hope Medical Center, Bosentan + Gemcitabine (NCT04158635)
- 2026-06-09Phase 3 first posted: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., Aprocitentan tablets(SYH9108) + Placebo (NCT07635914)
- 2026-03-30Results posted on the registry: Boehringer Ingelheim, BI 425809 + Bosentan (NCT05723874)
- 2026-01-20Results posted on the registry: AstraZeneca, Placebo (placebo matching zibotentan capsule and placebo matching dapagliflozin tablet) + Zibotentan + placebo (placebo matching dapagliflozin tablet) (NCT06269484)
- 2025-11-24Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, Tadalafil + Ambrisentan (NCT07245680)
- 2025-11-20Results posted on the registry: Travere Therapeutics, Inc., Sparsentan (NCT05856760)
- 2025-10-21Results posted on the registry: Janssen Pharmaceutical K.K., Macitentan (NCT05167825)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision