Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:08 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Duobrii Treatment of Acne Keloidalis Nuchae (AKN)
NCT05608499 · Icahn School of Medicine at Mount Sinai · PHASE3 · terminated · last registry update 2025-11-04 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Interim analysis did not show any significant differences between groups” | – | Registry record, Icahn School of Medicine at Mount Sinai |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against RARG within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-10-30Results posted on the registry: Memorial Sloan Kettering Cancer Center, Hu3F8 + GM-CSF (NCT03033303)
- 2026-08-27Results posted on the registry: Merck Sharp & Dohme LLC, Pembrolizumab + Vibostolimab (NCT04303169)
- 2026-08-13Results posted on the registry: Merck Sharp & Dohme LLC, Pembrolizumab + Quavonlimab (NCT04305041)
- 2026-07-07Also stopped (withdrawn): Peking Union Medical College Hospital, Roxadustat in combination with retinoic acid (NCT06020833)
- 2026-07-07Also stopped (withdrawn): Peking Union Medical College Hospital, sirolimus and ATRA + sirolimus (NCT04324411)
- 2026-06-12Results posted on the registry: Johns Hopkins University, Retinoic acid + Sham treatment (NCT03491267)
- 2026-06-04Phase 3 first posted: Beijing Anzhen Hospital, ATRA (NCT07626398)
- 2026-05-19Phase 3 first posted: Peking University People's Hospital, all-trans retinoic acid (ATRA) + Placebo (NCT07597395)
- 2026-03-31Phase 3 first posted: Quetzal Therapeutics, QTX-2101 + ATRA + IV arsenic trioxide (ATO) + ATRA (NCT07504458)
- 2026-03-31Phase 3 first posted: First Affiliated Hospital Xi'an Jiaotong University, ATRA + RIF (NCT07503730)
- 2025-12-22Phase 3 first posted: SDK Therapeutics, Inc., Oral ATO + IV Arsenic Trioxide (NCT07296445)
- 2025-12-18Also stopped (terminated): Mario Negri Institute for Pharmacological Research, all-trans retinoic acid + Anastrozole 1mg (NCT04113863)
- 2025-12-12Phase 3 first posted: Institute of Hematology & Blood Diseases Hospital, China, Avatrombopag+All trans retinoic acid + Avatrombopag (NCT07278908)
- 2025-11-14Results posted on the registry: University of Texas Southwestern Medical Center, a drug against RARG (NCT05493280)
- 2025-11-04Also stopped (terminated): Incyte Corporation, INCB059872 + all-trans retinoic acid (ATRA) (NCT02712905)
- 2025-10-30Results posted on the registry: Bausch Health Americas, Inc., IDP-126 Gel + IDP-126 Vehicle Gel (NCT04892706)
- 2025-10-09Results posted on the registry: Sun Pharmaceutical Industries Limited, Winlevi (clascoterone) 1% & Adapalene 0.3% gel (NCT06336603)
- 2025-09-22Phase 3 first posted: Galderma R&D, Trifarotene + Vehicle Cream (NCT07186413)
- 2025-07-24Phase 3 first posted: James Thomas Pathoulas, Tretinoin 0.1% cream + Bland cream (non-drug) (NCT07084116)
- 2025-06-13Results posted on the registry: Ipsen, Palovarotene (NCT05027802)
- 2025-04-10Results posted on the registry: Syros Pharmaceuticals, Tamibarotene + Placebo (NCT04797780)
- 2025-04-10Also stopped (terminated): Syros Pharmaceuticals, Tamibarotene + Placebo (NCT04797780)
- 2025-03-14Results posted on the registry: LEO Pharma, Delgocitinib + Toctino (NCT05259722)
- 2025-02-25Results posted on the registry: Hackensack Meridian Health, Daratumumab + Pomalidomide (NCT04700176)
- 2025-02-25Also stopped (terminated): Hackensack Meridian Health, Daratumumab + Pomalidomide (NCT04700176)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision