Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:07 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)
NCT05657457 · General Hospital of Shenyang Military Region · PHASE3 · terminated · last registry update 2025-07-02 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The interim analysis showed the potential harm of intra-arterial TNK.” | – | Registry record, General Hospital of Shenyang Military Region |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against PLAT within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-06-25Phase 3 first posted: The First Affiliated Hospital with Nanjing Medical University, Recombinant Tissue Plasminogen Activator (rt-PA) + Best Medical Management (NCT07668323)
- 2026-06-01Also stopped (terminated): Vanderbilt University, Bradykinin (NCT00868855)
- 2026-05-26Phase 3 first posted: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg) + Standard medical treatment (NCT07606807)
- 2026-05-18Also stopped (terminated): University Hospital Tuebingen, Tenecteplase (until trial protocol V04: Alteplase) (NCT04965038)
- 2026-04-29Also stopped (withdrawn): Centre hospitalier de l'Université de Montréal (CHUM), a drug against PLAT (NCT06034847)
- 2026-04-20Phase 3 first posted: The First Affiliated Hospital of Zhengzhou University, TNK-tPA + Aspirin (NCT07540416)
- 2026-04-14Also stopped (terminated): Kaiser Permanente, normal saline + TNK (Tenecteplase) (NCT01580618)
- 2026-03-17Phase 3 first posted: First Affiliated Hospital of Guangxi Medical University, Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) (NCT07475949)
- 2026-03-17Phase 3 first posted: First Hospital of China Medical University, Tenecteplase (0.25mg/kg) + Standard Medical Management (NCT07476898)
- 2026-03-13Phase 3 first posted: Beijing Tiantan Hospital, Standard medical treatment (NCT07471256)
- 2026-03-13Phase 3 first posted: Chuansheng Zhao, Tenecteplase (0.0938mg/kg) + Placebo (NCT07471282)
- 2026-01-23Phase 3 first posted: Boehringer Ingelheim, Tenecteplase + Standard of care treatment (NCT07361302)
- 2026-01-16Phase 3 first posted: Xinqiao Hospital of Chongqing, Eptifibatide (Integrilin) + Standard Medical Therapy (NCT07347626)
- 2025-12-24Phase 3 first posted: Xiang Luo, Standard medical treatment (NCT07302854)
- 2025-11-28Phase 3 first posted: Xuanwu Hospital, Beijing, Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) (NCT07253181)
- 2025-10-01Phase 3 first posted: CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd., rhTNK-tPA + Placebo (NCT07201688)
- 2025-09-11Phase 3 first posted: The First Affiliated Hospital of University of Science and Technology of China, TNK + Standard medical treatment (NCT07168278)
- 2025-09-09Phase 3 first posted: University of Illinois Chicago, Deferoxamine (NCT07162363)
- 2025-08-28Phase 3 first posted: AO GENERIUM, Revelise (GENERIUM, Russia) + Actilyse® (Boehringer Ingelheim Pharma GmbH and Co.KG, Germany) (NCT07146360)
- 2025-08-11Results posted on the registry: University College, London, Nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 1 + Nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 2 IMV (NCT04356833)
- 2025-07-30Phase 3 first posted: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) + Placebo (NCT07092709)
- 2025-07-25Also stopped (terminated): University Hospital, Caen, N-Acetyl cysteine (NCT04920448)
- 2025-07-25Also stopped (terminated): University Hospital, Caen, EVD + IVF with Alteplase (NCT03187405)
- 2025-07-18Phase 3 first posted: Second Affiliated Hospital, Zhejiang University, School of Medicine, Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) (NCT07073469)
- 2025-07-02Phase 3 first posted: Beijing Tiantan Hospital, Tenecteplase (0.25mg/kg) + Standard medical treatment (NCT07047014)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision