Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:57 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Brigatinib Post Definitive Chemo-radiotherapy in Patients with ALK-fusion Non-small Cell Lung Cancer
NCT05718297 · ETOP IBCSG Partners Foundation · PHASE2 · withdrawn · last registry update 2024-10-08 · Non-small cell lung cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Despite our efforts, the trial faced challenges like a longer activation period and slower accrual. We proposed a redesign, but TAKEDA withdrew. As a non-profit organisation, we can't continue without TAKEDA's support and must discontinue the trial.” | Open Targets' class: insufficient enrollment, study design | Registry record, ETOP IBCSG Partners Foundation |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against ALK in non-small cell lung cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-06-11Results posted on the registry: Pfizer, Lorlatinib (NCT04362072)
- 2025-05-13Results posted on the registry: Massachusetts General Hospital, Alectinib + Bevacizumab (NCT02521051)
- 2025-05-13Also stopped (terminated): Massachusetts General Hospital, Alectinib + Bevacizumab (NCT02521051)
- 2025-05-02Phase 3 first posted: The First Affiliated Hospital of Guangzhou Medical University, Icotinib + Rezivertinib (NCT06955325)
- 2025-04-24Also stopped (withdrawn): M.D. Anderson Cancer Center, Brigatinib + Carboplatin (NCT06522360)
- 2025-03-26Results posted on the registry: ETOP IBCSG Partners Foundation, Alectinib (NCT03445000)
- 2025-03-05Phase 3 first posted: Guangdong Association of Clinical Trials, lorlatinib (NCT06858410)
- 2025-02-19Results posted on the registry: Takeda, Brigatinib + Alectinib (NCT03596866)
- 2025-01-09Phase 3 first posted: Nuvalent Inc., Neladalkib (NVL-655) + Alectinib (NCT06765109)
- 2024-12-20Results posted on the registry: Pfizer, Lorlatinib (NCT04541706)
- 2024-11-08Results posted on the registry: Pfizer, Crizotinib (NCT03672643)
- 2024-11-08Also stopped (terminated): Pfizer, Crizotinib (NCT03672643)
- 2024-10-02Phase 3 first posted: Hoffmann-La Roche, Alectinib + Cisplatin (NCT06624059)
- 2024-08-26Results posted on the registry: Hoffmann-La Roche, Alectnib + Cisplatin (NCT03456076)
- 2024-08-26Phase 3 first posted: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a drug against ALK (NCT06569420)
- 2024-08-21Phase 3 first posted: Nuvation Bio Inc., Taletrectinib + Crizotinib (NCT06564324)
- 2024-04-26Also stopped (terminated): Suzhou Zelgen Biopharmaceuticals Co.,Ltd, Alkotinib Capsules (NCT04211922)
- 2024-02-12Phase 3 first posted: Shouyao Holdings (Beijing) Co. LTD, SY-3505 Capsules + Crizotinib Capsules (NCT06254599)
- 2023-12-13Also stopped (withdrawn): SCRI Development Innovations, LLC, Lorlatinib + Cisplatin or Carboplatin (NCT05948462)
- 2023-11-21Results posted on the registry: National Cancer Institute (NCI), Alectinib + Brigatinib (NCT03737994)
- 2023-11-20Phase 3 first posted: Bristol-Myers Squibb, Repotrectinib + Crizotinib (NCT06140836)
- 2023-10-13Phase 3 first posted: Shenzhen TargetRx Co., Ltd., TGRX-326 + Crizotinib (NCT06082635)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision