Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:55 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of Oral Decitabine/Cedazuridine in Combination With Magrolimab in Participants With Intermediate- to Very High-Risk Myelodysplastic Syndromes (MDS)
NCT05835011 · Astex Pharmaceuticals, Inc. · PHASE2 · terminated · last registry update 2024-10-02 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Termination due to discontinuation of magrolimab development in MDS.” | – | Registry record, Astex Pharmaceuticals, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against DNMT3A within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-09-30Also stopped (terminated): National Cancer Institute (NCI), Deoxyribonucleic acid (DNA) methyltransferase inhibitors (DNMTi) Decitabine + Deoxyribonucleic acid (DNA) methyltransferase inhibitors (DNMTi) Cedazuridine (NCT05148234)
- 2025-09-16Results posted on the registry: National Cancer Institute (NCI), Belinostat + Decitabine and Cedazuridine (NCT04340843)
- 2025-09-16Results posted on the registry: Massachusetts General Hospital, Oral Decitabine + Durvalumab (NCT03019003)
- 2025-08-29Also stopped (suspended): Johns Hopkins University, Decitabine (NCT04482621)
- 2025-08-26Results posted on the registry: Montefiore Medical Center, Venetoclax + Decitabine (NCT05184842)
- 2025-08-07Results posted on the registry: M.D. Anderson Cancer Center, Azacitidine (AZA) Days 1 - 3 + Decitabine (DAC) (NCT02269280)
- 2025-08-06Also stopped (withdrawn): M.D. Anderson Cancer Center, Cladribine + Cytarabine (NCT06474663)
- 2025-07-31Results posted on the registry: Novartis Pharmaceuticals, MBG453 + Azacitidine (NCT04878432)
- 2025-07-04Phase 3 first posted: Nanfang Hospital, Southern Medical University, Venetoclax (VEN) + Decitabine (DAC) (NCT07052422)
- 2025-05-30Also stopped (withdrawn): Institute of Hematology & Blood Diseases Hospital, China, Decitabine (NCT03021395)
- 2025-05-25Also stopped (withdrawn): City of Hope Medical Center, Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001 + Cyclophosphamide (NCT06572631)
- 2025-05-15Phase 3 first posted: Ruijin Hospital, Decitabine + Sorafenib (BAY-43-9006),giritinib (NCT06972641)
- 2025-04-24Also stopped (terminated): Seoul National University Hospital, Decitabine with GemOx + GemOx (NCT06941688)
- 2025-04-22Also stopped (withdrawn): University of Florida, Cladribine + Cytarabine (NCT05766514)
- 2025-03-24Also stopped (withdrawn): Columbia University, Thioguanine (Tabloid ®) + DecitabineCedazuridine (Inqovi ®) (NCT06351306)
- 2025-03-24Also stopped (terminated): Luca Cardone, Decitabine 50 MG [Dacogen] (NCT05360264)
- 2025-03-12Also stopped (withdrawn): M.D. Anderson Cancer Center, ASTX727 + ASTX029-01 (NCT06113289)
- 2025-01-07Results posted on the registry: National Cancer Institute (NCI), Decitabine + Ipilimumab (NCT02890329)
- 2024-12-19Results posted on the registry: BerGenBio ASA, Bemcentinib + Cytarabine (NCT02488408)
- 2024-12-03Phase 3 first posted: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS, High intensity therapies + Low intensity therapies (NCT06713837)
- 2024-10-22Results posted on the registry: National Cancer Institute (NCI), Decitabine + Nivolumab (NCT04277442)
- 2024-08-02Also stopped (terminated): Astex Pharmaceuticals, Inc., ASTX660 + ASTX727 (NCT04155580)
- 2024-07-23Results posted on the registry: National Cancer Institute (NCI), Azacitidine + Cytarabine (NCT03092674)
- 2024-07-03Also stopped (withdrawn): Case Comprehensive Cancer Center, INQOVI (decitabine and cedazuridine) + Nivolumab (NCT06357858)
- 2024-07-01Results posted on the registry: Astex Pharmaceuticals, Inc., ASTX727 + Dacogen (NCT03306264)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision