Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:09 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Phase 1B/2A Trial of Combination of ASTX727 With ASTX029 in Acute Myeloid Leukemia
NCT06113289 · M.D. Anderson Cancer Center · PHASE1/PHASE2 · withdrawn · last registry update 2025-03-12 · Acute myeloid leukemia · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “PI Request” | Open Targets' class: business administrative | Registry record, M.D. Anderson Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against DNMT3A in acute myeloid leukemia within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-03-10Also stopped (terminated): M.D. Anderson Cancer Center, Decitabine + Venetoclax (NCT03404193)
- 2026-02-27Results posted on the registry: Roswell Park Cancer Institute, DEC-205/NY-ESO-1 Fusion Protein CDX-1401 + Decitabine (NCT03358719)
- 2026-01-09Results posted on the registry: Sanjay Mohan, Venetoclax + Decitabine (NCT05799079)
- 2026-01-09Also stopped (terminated): Sanjay Mohan, Venetoclax + Decitabine (NCT05799079)
- 2025-11-05Results posted on the registry: University of Nebraska, Cytarabine + Decitabine (NCT03226418)
- 2025-08-26Results posted on the registry: Montefiore Medical Center, Venetoclax + Decitabine (NCT05184842)
- 2025-05-30Also stopped (withdrawn): Institute of Hematology & Blood Diseases Hospital, China, Decitabine (NCT03021395)
- 2025-05-25Also stopped (withdrawn): City of Hope Medical Center, Allogeneic CD8+ Leukemia-associated Antigens Specific T Cells NEXI-001 + Cyclophosphamide (NCT06572631)
- 2025-05-15Phase 3 first posted: Ruijin Hospital, Decitabine + Sorafenib (BAY-43-9006),giritinib (NCT06972641)
- 2025-04-22Also stopped (withdrawn): University of Florida, Cladribine + Cytarabine (NCT05766514)
- 2025-03-24Also stopped (withdrawn): Columbia University, Thioguanine (Tabloid ®) + DecitabineCedazuridine (Inqovi ®) (NCT06351306)
- 2025-01-07Results posted on the registry: National Cancer Institute (NCI), Decitabine + Ipilimumab (NCT02890329)
- 2024-12-19Results posted on the registry: BerGenBio ASA, Bemcentinib + Cytarabine (NCT02488408)
- 2024-12-03Phase 3 first posted: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS, High intensity therapies + Low intensity therapies (NCT06713837)
- 2024-10-22Results posted on the registry: National Cancer Institute (NCI), Decitabine + Nivolumab (NCT04277442)
- 2024-08-02Also stopped (terminated): Astex Pharmaceuticals, Inc., ASTX660 + ASTX727 (NCT04155580)
- 2024-07-23Results posted on the registry: National Cancer Institute (NCI), Azacitidine + Cytarabine (NCT03092674)
- 2024-07-01Results posted on the registry: Astex Pharmaceuticals, Inc., ASTX727 + Dacogen (NCT03306264)
- 2024-06-14Also stopped (withdrawn): Northside Hospital, Inc., Venetoclax + Decitabine (NCT06337331)
- 2024-03-29Also stopped (terminated): Technische Universität Dresden, Eltrombopag + Placebo (NCT02446145)
- 2024-03-22Also stopped (terminated): Kartos Therapeutics, Inc., KRT-232 + Cytarabine (NCT04113616)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision