Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:55 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of Chenodeoxycholic Acid (CDCA) in Newly Diagnosed Participants With Cerebrotendinous Xanthomatosis (CTX)
NCT06260748 · Leadiant Biosciences, Inc. · PHASE3 · withdrawn · last registry update 2024-11-18 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Lack of feasibility” | – | Registry record, Leadiant Biosciences, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against NR1H4 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-03-12Results posted on the registry: Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA), TERN-501 + TERN-101 (NCT05415722)
- 2025-02-25Results posted on the registry: Gilead Sciences, Placebo Comparator + Experimental: Seladelpar 50 mg (NCT02609048)
- 2025-02-25Also stopped (terminated): Gilead Sciences, Placebo Comparator + Experimental: Seladelpar 50 mg (NCT02609048)
- 2025-02-24Results posted on the registry: Capricor Inc., CAP-1002 + Placebo (NCT03406780)
- 2025-02-20Results posted on the registry: Capricor Inc., CAP-1002 + Placebo (NCT04623671)
- 2025-01-28Also stopped (terminated): Novartis Pharmaceuticals, Tropifexor + Licogliflozin (NCT04065841)
- 2025-01-01Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate (NCT06755151)
- 2025-01-01Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate in Combination With Ursodeoxycholic Acid (NCT06755541)
- 2024-12-04Phase 3 first posted: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., OCA + UDCA (NCT06715319)
- 2024-10-28Results posted on the registry: Mirum Pharmaceuticals, Inc., Blinded CDCA 250 mg TID + Placebo (NCT04270682)
- 2024-09-19Phase 3 first posted: Han Ying, Prednisone + UDCA (Ursodeoxycholic acid) (NCT06591468)
- 2024-09-05Results posted on the registry: Ipsen, Elafibranor 80mg + Placebo (NCT04526665)
- 2024-07-25Results posted on the registry: Gilead Sciences, Seladelpar 10 mg + Placebo (NCT04620733)
- 2024-07-16Results posted on the registry: University of Maryland, Baltimore, pravastatin and chenodeoxycholic acid, after metformin and placebo + valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo (NCT04640571)
- 2024-07-05Phase 3 first posted: Intercept Pharmaceuticals, FDC tablet (OCA 5 mg + BZF 400 mg SR) (NCT06488911)
- 2024-06-05Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, Bezafibrate 400 mg in addition to UDCA therapy + Bezafibrate 200 mg in addition to UDCA therapy (NCT06443606)
- 2024-05-16Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Dapagliflozin (NCT06415773)
- 2024-04-25Phase 3 first posted: Ipsen, Elafibranor (NCT06383403)
- 2024-04-15Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate + UDCA (NCT06365424)
- 2024-04-09Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Placebo (NCT06353347)
- 2024-04-09Also stopped (terminated): Nottingham University Hospitals NHS Trust, Ursodeoxycholic acid (NCT05526807)
- 2024-04-08Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Placebo (NCT06350890)
- 2024-03-06Phase 3 first posted: Hopital Foch, Ursolvan + Placebo (NCT06294847)
- 2024-02-06Also stopped (terminated): Intercept Pharmaceuticals, INT-747 + Ursodeoxycholic Acid (URSO) (NCT00550862)
- 2023-12-26Results posted on the registry: Novartis Pharmaceuticals, Tropifexor + Licogliflozin (NCT04065841)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision