Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 00:09 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
NCT06284460 · M.D. Anderson Cancer Center · PHASE1/PHASE2 · withdrawn · last registry update 2026-02-13 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Drug Source Request” | – | Registry record, M.D. Anderson Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against DNMT3A within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-10-23Results posted on the registry: The First Affiliated Hospital of Soochow University, Decitabine + Granulocyte Colony-Stimulating Factor (NCT05907499)
- 2026-10-20Also stopped (suspended): City of Hope Medical Center, Decitabine + Pembrolizumab (NCT03969446)
- 2026-10-08Also stopped (terminated): Taiho Oncology, Inc., Tolinapant + Decitabine + Cedazuridine (NCT05403450)
- 2026-10-06Results posted on the registry: National Cancer Institute (NCI), Cytarabine + Daunorubicin (NCT04817241)
- 2026-08-24Also stopped (suspended): National Cancer Institute (NCI), Decitabine and Cedazuridine + Venetoclax (NCT06802523)
- 2026-08-12Phase 3 first posted: Shanghai Jiao Tong University School of Medicine, Unrelated Umbilical Cord Blood Infusion + Standard consolidation chemotherapy with high-dose cytarabine (NCT07761702)
- 2026-07-31Also stopped (suspended): National Cancer Institute (NCI), Decitabine and Cedazuridine + Paclitaxel (NCT05673200)
- 2026-07-20Phase 3 first posted: The Second Affiliated Hospital of Kunming Medical University, a drug against DNMT3A (NCT07712848)
- 2026-06-22Also stopped (withdrawn): Case Comprehensive Cancer Center, Decitabine + Nivolumab (NCT07216833)
- 2026-06-08Results posted on the registry: University of Southern California, Azacitidine + Decitabine (NCT03146871)
- 2026-06-08Also stopped (terminated): University of Southern California, Azacitidine + Decitabine (NCT03146871)
- 2026-05-15Also stopped (withdrawn): M.D. Anderson Cancer Center, ASTX727 + Donor Lymphocyte Infusion (NCT06297629)
- 2026-04-24Results posted on the registry: Washington University School of Medicine, CIML NK Cell Infusion (NCT03068819)
- 2026-04-23Also stopped (suspended): Sclnow Biotechnology Co., Ltd., Allogeneic umbilical cord mesenchymal stem cells + Decitabine (NCT03184935)
- 2026-04-06Phase 3 first posted: Ruijin Hospital, C-Pola-R-CHP+X + CR-CHOP (NCT07511114)
- 2026-03-10Also stopped (terminated): M.D. Anderson Cancer Center, Decitabine + Venetoclax (NCT03404193)
- 2026-02-27Results posted on the registry: Roswell Park Cancer Institute, DEC-205/NY-ESO-1 Fusion Protein CDX-1401 + Decitabine (NCT03358719)
- 2026-02-11Also stopped (terminated): Institute of Hematology & Blood Diseases Hospital, China, Decitabine (NCT04854889)
- 2026-01-22Also stopped (terminated): Delta-Fly Pharma, Inc., DFP-10917 + Cytarabine (NCT03926624)
- 2026-01-16Phase 3 first posted: Second Affiliated Hospital of Nanchang University, R-CHOP + Decitabine in combination with R-CHOP (NCT07348575)
- 2026-01-13Also stopped (terminated): Novartis Pharmaceuticals, MBG453 + Placebo (NCT03946670)
- 2026-01-09Results posted on the registry: Sanjay Mohan, Venetoclax + Decitabine (NCT05799079)
- 2026-01-09Also stopped (terminated): Sanjay Mohan, Venetoclax + Decitabine (NCT05799079)
- 2025-12-02Results posted on the registry: National Cancer Institute (NCI), KPT-8602 + Inqovi (NCT05918055)
- 2025-12-02Also stopped (terminated): National Cancer Institute (NCI), KPT-8602 + Inqovi (NCT05918055)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision