Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:28 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)
NCT06408168 · M.D. Anderson Cancer Center · PHASE2 · terminated · last registry update 2026-01-05 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “\<75% Participation” | – | Registry record, M.D. Anderson Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against ESR1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-10-23Phase 3 first posted: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Fulvestrant + Pyrotinib (NCT07892274)
- 2026-10-15Also stopped (terminated): Spanish Breast Cancer Research Group, Trastuzumab + Alpelisib (NCT05063786)
- 2026-10-14Also stopped (terminated): UNICANCER, Alpelisib + Ribociclib (NCT05625087)
- 2026-10-06Also stopped (terminated): Boehringer Ingelheim, BI 3031185 + Placebo matching BI 3031185 (NCT07656792)
- 2026-09-30Results posted on the registry: Teva Pharmaceuticals USA, Estradiol + Imvexxy (NCT05617820)
- 2026-09-25Results posted on the registry: Memorial Sloan Kettering Cancer Center, Fulvestrant + Abemaciclib (NCT03643510)
- 2026-09-25Results posted on the registry: Dartmouth-Hitchcock Medical Center, 17B-estradiol + Letrozole (NCT02188745)
- 2026-09-24Results posted on the registry: Tvardi Therapeutics, Incorporated, TTI-101 + Palbociclib (NCT05384119)
- 2026-09-24Also stopped (terminated): Tvardi Therapeutics, Incorporated, TTI-101 + Palbociclib (NCT05384119)
- 2026-09-24Results posted on the registry: Stephanie Wang Zuo, Periurethral application of estradiol cream + Intravaginal application of estradiol cream (NCT05472779)
- 2026-09-24Results posted on the registry: University of Wisconsin, Madison, Indomethacin + Placebo (NCT06253702)
- 2026-09-14Results posted on the registry: Mylan Technologies Inc., MR-100A-01 (NCT05139121)
- 2026-09-03Phase 3 first posted: SWOG Cancer Research Network, NSAI + CDK4/6i + NSAI + CDK4/6i + Capivasertib (NCT07802626)
- 2026-08-27Results posted on the registry: Insud Pharma, Twirla® (Levonorgestrel/Ethinyl Estradiol) Transdermal System (NCT07739589)
- 2026-08-25Phase 3 first posted: Chengdu JOYO pharma Co., Ltd., JYP0035 plus Fulvestrant + JYP0035 placebo plus Fulvestrant (NCT07784036)
- 2026-08-19Also stopped (terminated): Boundless Bio, Inc., BBI-940 + Fulvestrant (NCT07408089)
- 2026-08-07Results posted on the registry: Priscilla McAuliffe, Tamoxifen + Anastrozole (NCT02206984)
- 2026-07-22Results posted on the registry: Emory University, Estradiol patch (NCT03973229)
- 2026-07-21Results posted on the registry: Context Therapeutics Inc., Elacestrant + Onapristone (NCT05618613)
- 2026-07-21Also stopped (terminated): Context Therapeutics Inc., Elacestrant + Onapristone (NCT05618613)
- 2026-07-20Phase 3 first posted: Eurofarma Laboratorios S.A., Cyproterone Acetate 2 mg and Ethinyl Estradiol 0.02 mg (NCT07714616)
- 2026-07-10Results posted on the registry: Novartis Pharmaceuticals, Ribociclib + Letrozole (NCT03439046)
- 2026-07-10Also stopped (terminated): Novartis Pharmaceuticals, Ribociclib + Letrozole (NCT03439046)
- 2026-07-06Results posted on the registry: Estetra, Estetrol (NCT06308614)
- 2026-06-25Results posted on the registry: Novartis Pharmaceuticals, Alpelisib + Fulvestrant (NCT05631795)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision