Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:09 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Brigatinib Plus Chemotherapy or Local Consolidation Therapy in ALK Positive Advanced Non-small Cell Lung Cancer (BrightStar-2)
NCT06522360 · M.D. Anderson Cancer Center · PHASE2 · withdrawn · last registry update 2025-04-24 · Non-small cell lung cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “0 participants enrolled” | Open Targets' class: insufficient enrollment | Registry record, M.D. Anderson Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against ALK in non-small cell lung cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-04-23Also stopped (terminated): National Cancer Institute (NCI), Alectinib + Brigatinib (NCT03737994)
- 2025-06-11Results posted on the registry: Pfizer, Lorlatinib (NCT04362072)
- 2025-05-13Results posted on the registry: Massachusetts General Hospital, Alectinib + Bevacizumab (NCT02521051)
- 2025-05-13Also stopped (terminated): Massachusetts General Hospital, Alectinib + Bevacizumab (NCT02521051)
- 2025-05-02Phase 3 first posted: The First Affiliated Hospital of Guangzhou Medical University, Icotinib + Rezivertinib (NCT06955325)
- 2025-03-26Results posted on the registry: ETOP IBCSG Partners Foundation, Alectinib (NCT03445000)
- 2025-03-05Phase 3 first posted: Guangdong Association of Clinical Trials, lorlatinib (NCT06858410)
- 2025-02-19Results posted on the registry: Takeda, Brigatinib + Alectinib (NCT03596866)
- 2025-01-09Phase 3 first posted: Nuvalent Inc., Neladalkib (NVL-655) + Alectinib (NCT06765109)
- 2024-12-20Results posted on the registry: Pfizer, Lorlatinib (NCT04541706)
- 2024-11-08Results posted on the registry: Pfizer, Crizotinib (NCT03672643)
- 2024-11-08Also stopped (terminated): Pfizer, Crizotinib (NCT03672643)
- 2024-10-08Also stopped (withdrawn): ETOP IBCSG Partners Foundation, Brigatinib + Durvalumab (NCT05718297)
- 2024-10-02Phase 3 first posted: Hoffmann-La Roche, Alectinib + Cisplatin (NCT06624059)
- 2024-08-26Results posted on the registry: Hoffmann-La Roche, Alectnib + Cisplatin (NCT03456076)
- 2024-08-26Phase 3 first posted: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a drug against ALK (NCT06569420)
- 2024-08-21Phase 3 first posted: Nuvation Bio Inc., Taletrectinib + Crizotinib (NCT06564324)
- 2024-04-26Also stopped (terminated): Suzhou Zelgen Biopharmaceuticals Co.,Ltd, Alkotinib Capsules (NCT04211922)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision