Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:19 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Investigate the Sequencing Strategy of Pirtobrutinib After Disease Progression on First-line Acalabrutinib Treatment for Adult Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06839872 · AstraZeneca · PHASE2 · withdrawn · last registry update 2025-06-05 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “AstraZeneca has made the decision to cancel the trial.” | – | Registry record, AstraZeneca |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against BTK within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-05-22Results posted on the registry: University of California, San Diego, Ibrutinib 560mg PO daily (Imbruvica) + Cetuximab (NCT03646461)
- 2026-05-22Also stopped (terminated): University of California, San Diego, Ibrutinib 560mg PO daily (Imbruvica) + Cetuximab (NCT03646461)
- 2026-05-22Also stopped (terminated): Mayo Clinic, Ibrutinib (NCT06271616)
- 2026-05-05Also stopped (terminated): Mayo Clinic, Ibrutinib + Ixazomib Citrate (NCT03506373)
- 2026-04-30Phase 3 first posted: Shandong University, High-Dose Dexamethasone Combined with Orelabrutinib + High-Dose Dexamethasone Combined with Placebo (NCT07559331)
- 2026-04-27Also stopped (terminated): Xuanwu Hospital, Beijing, zanubrutinib (NCT05356858)
- 2026-04-07Phase 3 first posted: Nurix Therapeutics, Inc., NX-5948 + Pirtobrutinib (NCT07516093)
- 2026-04-02Results posted on the registry: National Cancer Institute (NCI), Cyclophosphamide + Doxorubicin Hydrochloride (NCT03220022)
- 2026-04-01Results posted on the registry: Matthew C. Baker, Zanubrutinib 80 MG (NCT04602598)
- 2026-03-25Results posted on the registry: BeiGene, Zanubrutinib (NCT05068440)
- 2026-03-17Results posted on the registry: Pharmacyclics LLC., Ibrutinib Oral Capsule + Placebo (NCT02947347)
- 2026-03-02Also stopped (terminated): H. Lee Moffitt Cancer Center and Research Institute, Pembrolizumab + Ibrutinib (NCT03514017)
- 2026-02-23Results posted on the registry: Principia Biopharma, a Sanofi Company, Rilzabrutinib + Placebo (NCT04562766)
- 2026-02-20Results posted on the registry: BeiGene, BGB-10188 + Zanubrutinib (NCT04282018)
- 2026-02-02Results posted on the registry: National Cancer Institute (NCI), Ibrutinib + Obinutuzumab (NCT03737981)
- 2026-01-30Phase 3 first posted: Guangzhou Lupeng Pharmaceutical Company LTD., Rocbrutinib + Ibrutinib (NCT07377578)
- 2026-01-27Results posted on the registry: Kerry Rogers, Bcl-2 Inhibitor GDC-0199 + Obinutuzumab (NCT02427451)
- 2026-01-15Phase 3 first posted: Newave Pharmaceutical Inc, Rocbrutinib + Pirtobrutinib (NCT07342478)
- 2026-01-07Phase 3 first posted: Alliance for Clinical Trials in Oncology, Zanubrutinib + Sonrotoclax (NCT07321652)
- 2025-12-23Phase 3 first posted: Zenas BioPharma (USA), LLC, Orelabrutinib + Placebo (NCT07299019)
- 2025-12-11Phase 3 first posted: BeOne Medicines, Sonrotoclax + Zanubrutinib (NCT07277231)
- 2025-11-14Results posted on the registry: Principia Biopharma, a Sanofi Company, Rilzabrutinib (NCT03395210)
- 2025-10-23Phase 3 first posted: SWOG Cancer Research Network, Cyclophosphamide + Doxorubicin Hydrochloride (NCT07220187)
- 2025-10-15Results posted on the registry: Acerta Pharma BV, acalabrutinib + rituximab (IV) (NCT02180711)
- 2025-10-14Phase 3 first posted: Sanofi, rilzabrutinib (NCT07216079)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision