GRM2 glutamate metabotropic receptor 2
ENSG00000164082 · protein coding · Open Targets profile
Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000250|UniProtKB:Q14BI2, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:37286794, ECO:0000269|PubMed:7620613}.
Each band is a group of drugs. It runs from the kind of drug on the left to the furthest stage that drug has reached in any disease on the right. Thicker bands mean more drugs.
Approved bands are highlighted. Withdrawn means the drug was pulled from the market or from development. A combined phase counts as the later one (Phase 1/2 is shown as Phase 2). Hover a band for the drug names. Source: Open Targets Platform, fetched live.
Each row is a cancer, strongest overall evidence first. The two dots show how strong the inherited (germline) and tumour-mutation (somatic) evidence is; the line between them is the gap.
Scores run from 0 (no evidence) to 1 (strongest). A missing dot at 0 means Open Targets holds no evidence of that kind. Source: Open Targets Platform, fetched live.
Tractability
- Small molecule
- Advanced Clinical, Structure with Ligand, High-Quality Ligand, Druggable Family
- Antibody
- GO CC high conf, UniProt loc med conf, UniProt SigP or TMHMM
- PROTAC
- Half-life Data, Small Molecule Binder
gnomAD loss of function constraint: o/e 0.5797899961471558 (upper bound 0.7687000036239624). Low values mean loss of function is poorly tolerated, a safety flag for inhibition.
Who runs trials of these drugs
No named investigators on registry trials of GRM2's approved or late-stage drugs in the last three years.
Registry trials of LY404039, pomaglumetad methionil anhydrous, JNJ-40411813, decoglurant updated in the last three years, counted by the country group of their listed sites. A trial with sites in several groups counts in each; 2 of 3 have all sites in one country.
Site counts are not patients per country, and trials registered only outside ClinicalTrials.gov are not covered. Where sites are is a fact about the record, not a judgement of its quality. Europe is the EU and EEA, the UK and Switzerland. Source: ClinicalTrials.gov, fetched live.
2 trials of drugs against GRM2 were stopped early
Terminated, withdrawn and suspended interventional trials of LY404039, pomaglumetad methionil anhydrous, JNJ-40411813, decoglurant, LY2979165, newest update first, live from ClinicalTrials.gov. Each reason is quoted exactly as the registry gives it; we do not sort reasons into safety, efficacy or business. Dates are the last registry update. Showing the 2 most recent of 2.
- withdrawn · 2021-08-23 · Denovo Biopharma LLC · matched by the registry's drug synonyms“The decision to stop the trial was based on efficacy results in the overall schizophrenia patient population.”
- terminated · 2021-04-01 · Mediti Pharma Inc. · matched by the registry's drug synonyms“Statistical futility; totality of evidence suggests study unlikely to meet endpoint”
Paediatric incentives and obligations for GRM2's drugs
For LY404039, pomaglumetad methionil anhydrous, JNJ-40411813, decoglurant, LY2979165: what EMA and FDA publish about paediatric plans, orphan status and pediatric approvals, and how many registered studies take children. Each line is a yes, no or not published fact from the record linked under it; none of it is a forecast.
- FDA pediatric target list: no · GRM2 is not on the listRule: Target is on FDA's Pediatric Molecular Target List (relevant targets). Source: FDA Pediatric Molecular Target List (Listed as February 2026 on the FDA Pediatric Oncology page; the file served is 9.7.22_the_relevant_molecular_target_list.xlsx, whose Summary of Changes sheet is headed 'SEPTEMBER 2022 UPDATE' (footnote date 2022-09-01)), 2026-11-11
- EU paediatric investigation plan: no · No EMA paediatric investigation plan decision names ly404039, pomaglumetad methionil anhydrous, jnj-40411813, decoglurant, ly2979165Rule: An EMA PIP decision (agreement, modification or waiver) lists the drug as its active substance, exact name. Source: EMA data download (dated snapshot), 2026-11-11
- EU orphan designation: no · No EU orphan designation names ly404039, pomaglumetad methionil anhydrous, jnj-40411813, decoglurant, ly2979165Rule: An EU orphan designation lists the drug as its active substance (exact name) or belongs to a medicine that does; withdrawn and expired designations are listed with their status. Source: EMA data download (dated snapshot), 2026-11-11
- Authorised in the EU: no · EMA lists no centrally authorised medicine of ly404039, pomaglumetad methionil anhydrous, jnj-40411813, decoglurant, ly2979165Rule: An EMA medicine record lists the drug as its active substance or INN, exact name; national-only authorisations are not in this file. Source: EMA data download (dated snapshot), 2026-11-11
- FDA orphan designation: not published · FDA's orphan designation database turns away automated requests, so this app does not read it; search it by hand at the linkRule: Would be: an FDA orphan designation names the drug. Source: FDA orphan designations search
- FDA pediatric oncology approval: no · FDA's table lists no pediatric approval of ly404039, pomaglumetad methionil anhydrous, jnj-40411813, decoglurant, ly2979165Rule: FDA's Pediatric Oncology Drug Approvals table names the drug. Source: FDA Pediatric Oncology Drug Approvals (content current as of 2026-03-03), 2026-11-12
- Registered studies open to children: no · No interventional study of ly404039, pomaglumetad methionil anhydrous, jnj-40411813, decoglurant, ly2979165 includes patients under 18Rule: The registry's age group includes Child (birth to 17 years), which also counts studies that set no minimum age. Source: ClinicalTrials.gov search, 2026-11-12
Rare pediatric disease voucher. FDA, content current as of 29 Apr 2026: “As of February 3, 2026, enactment of the Consolidated Appropriations Act, 2026, the rare pediatric disease PRV program will sunset after September 30, 2029. FDA may not award any PRVs under this program after September 30, 2029.” Voucher sale prices are not shown here; they appear only as company-reported news. FDA: Rare Pediatric Disease Designation and Priority Review Voucher Programs
All 5 drugs and clinical candidates as a table
Each drug, stage and indication links to its Open Targets record, where the trials and approvals behind it are listed. Salt forms (for example a mesylate) are listed as Open Targets records them, as separate entries.
| Drug | Type | Highest stage | Indications | Source records |
|---|---|---|---|---|
| LY404039 | Small molecule | phase 3 | schizophrenia | Open Targets · ChEMBL |
| POMAGLUMETAD METHIONIL ANHYDROUS | Small molecule | phase 3 | schizophrenia, psychotic disorder | Open Targets · ChEMBL |
| JNJ-40411813 | Small molecule | phase 2 | anxiety disorder, psychiatric disorder, epilepsy, schizophrenia, major depressive disorder, Seizure, psychotic disorder | Open Targets · ChEMBL |
| DECOGLURANT | Small molecule | phase 2 | major depressive disorder | Open Targets · ChEMBL |
| LY2979165 | Small molecule | phase 1 | bipolar disorder | Open Targets · ChEMBL |