AMY2A amylase alpha 2A
ENSG00000243480 · protein coding · Open Targets profile
Each row is a cancer, strongest overall evidence first. The two dots show how strong the inherited (germline) and tumour-mutation (somatic) evidence is; the line between them is the gap.
Scores run from 0 (no evidence) to 1 (strongest). A missing dot at 0 means Open Targets holds no evidence of that kind. Source: Open Targets Platform, fetched live.
Tractability
- Small molecule
- Structure with Ligand, High-Quality Ligand, Med-Quality Pocket, Druggable Family
- Antibody
- GO CC high conf, UniProt loc med conf, UniProt SigP or TMHMM
- PROTAC
- Small Molecule Binder
- Other modalities
- Approved Drug
gnomAD loss of function constraint: o/e 0.3718299865722656 (upper bound 0.5647500157356262). Low values mean loss of function is poorly tolerated, a safety flag for inhibition.
Who runs trials of these drugs
Principal investigators and study chairs on 14 registry trials, updated in the last three years, of the most advanced drugs against AMY2A (acarbose), ranked by Phase 2+ trials. Live from ClinicalTrials.gov.
- Emmanuel COSSONAssistance Publique - Hôpitaux de Paris · 1 of 1 trials Phase 2+
- Faria AfsanaAssociate Professor, BIRDEM · 1 of 1 trials Phase 2+
- Helena LitorpCTC Clinical Trial Consultants AB · 1 of 1 trials Phase 2+
- Nir F BarzilaiAlbert Einstein College of Medicine Montefiore Medical Center · 1 of 1 trials Phase 2+
- Mette B LarsenAarhus University Hospital · 0 of 1 trials Phase 2+
Registry trials of acarbose updated in the last three years, counted by the country group of their listed sites. A trial with sites in several groups counts in each; 10 of 12 have all sites in one country.
Site counts are not patients per country, and trials registered only outside ClinicalTrials.gov are not covered. Where sites are is a fact about the record, not a judgement of its quality. Europe is the EU and EEA, the UK and Switzerland. 2 trials list no sites and are left out. Source: ClinicalTrials.gov, fetched live.
9 trials of drugs against AMY2A were stopped early; 1 give no reason
Terminated, withdrawn and suspended interventional trials of acarbose, newest update first, live from ClinicalTrials.gov. Each reason is quoted exactly as the registry gives it; we do not sort reasons into safety, efficacy or business. Dates are the last registry update. Showing the 9 most recent of 9.
- withdrawn · 2026-02-17 · University of Alabama at Birmingham · Acarbose Tablets“due to overall cost of the study”
- terminated · 2025-06-24 · Montefiore Medical Center · Acarbose“Upon review it was determined that the study terminated early due to lack of funding. Study never reached enrollment target and was administratively closed out by the Albert Einstein College of Medicine IRB.”
- terminated · 2024-11-12 · Astellas Pharma Inc · acarbose“Discontinued due to company's strategic reason”
- terminated · 2024-07-03 · Assistance Publique - Hôpitaux de Paris · Acarbose“difficulty in recruiting”
- terminated · 2021-12-07 · AstraZeneca · Acarbose“Study overall progress behind of scheduled timeline. Study was terminated early due to company decision.”
- terminated · 2019-10-09 · Eli Lilly and Company · Acarbose“The trial was terminated per protocol because of lack of feasibility.”
- terminated · 2013-08-19 · The Hospital for Sick Children · Acarbose“poor recruitment and no student currently interested in working on this project.”
- terminated · 2013-05-01 · Yale University · AcarboseNo reason given
- terminated · 2011-11-10 · Sanofi · matched by the registry's drug synonyms“due to poor recruitment”
Paediatric incentives and obligations for AMY2A's drugs
For acarbose: what EMA and FDA publish about paediatric plans, orphan status and pediatric approvals, and how many registered studies take children. Each line is a yes, no or not published fact from the record linked under it; none of it is a forecast.
- FDA pediatric target list: no · AMY2A is not on the listRule: Target is on FDA's Pediatric Molecular Target List (relevant targets). Source: FDA Pediatric Molecular Target List (Listed as February 2026 on the FDA Pediatric Oncology page; the file served is 9.7.22_the_relevant_molecular_target_list.xlsx, whose Summary of Changes sheet is headed 'SEPTEMBER 2022 UPDATE' (footnote date 2022-09-01)), 2026-11-11
- EU paediatric investigation plan: no · No EMA paediatric investigation plan decision names acarboseRule: An EMA PIP decision (agreement, modification or waiver) lists the drug as its active substance, exact name. Source: EMA data download (dated snapshot), 2026-11-11
- EU orphan designation: no · No EU orphan designation names acarboseRule: An EU orphan designation lists the drug as its active substance (exact name) or belongs to a medicine that does; withdrawn and expired designations are listed with their status. Source: EMA data download (dated snapshot), 2026-11-11
- Authorised in the EU: no · EMA lists no centrally authorised medicine of acarboseRule: An EMA medicine record lists the drug as its active substance or INN, exact name; national-only authorisations are not in this file. Source: EMA data download (dated snapshot), 2026-11-11
- FDA orphan designation: not published · FDA's orphan designation database turns away automated requests, so this app does not read it; search it by hand at the linkRule: Would be: an FDA orphan designation names the drug. Source: FDA orphan designations search
- FDA pediatric oncology approval: no · FDA's table lists no pediatric approval of acarboseRule: FDA's Pediatric Oncology Drug Approvals table names the drug. Source: FDA Pediatric Oncology Drug Approvals (content current as of 2026-03-03), 2026-11-11
- Registered studies open to children: yes · 5 interventional studies of acarbose include patients under 18; 0 are recruiting, not yet recruiting or activeRule: The registry's age group includes Child (birth to 17 years), which also counts studies that set no minimum age. Source: ClinicalTrials.gov search, 2026-11-11
Rare pediatric disease voucher. FDA, content current as of 29 Apr 2026: “As of February 3, 2026, enactment of the Consolidated Appropriations Act, 2026, the rare pediatric disease PRV program will sunset after September 30, 2029. FDA may not award any PRVs under this program after September 30, 2029.” Voucher sale prices are not shown here; they appear only as company-reported news. FDA: Rare Pediatric Disease Designation and Priority Review Voucher Programs
All 1 drugs and clinical candidates as a table
Each drug, stage and indication links to its Open Targets record, where the trials and approvals behind it are listed. Salt forms (for example a mesylate) are listed as Open Targets records them, as separate entries.
| Drug | Type | Highest stage | Indications | Source records |
|---|---|---|---|---|
| ACARBOSE | Oligosaccharide | phase 4 | type 2 diabetes mellitus, diabetes mellitus, cardiovascular disorder, endothelial dysfunction, atherosclerosis, gestational diabetes, non-alcoholic fatty liver, postprandial hypotension, +7 more | Open Targets · ChEMBL |