Diffuse midline glioma (DIPG)
H3 K27-altered tumours of the brainstem and midline, with no curative treatment: ONC201 and cell therapy trials.
Principal investigators and study chairs named on the registry for diffuse midline glioma (dipg), ranked by a published score: 3 per Phase 2+ trial they lead, 1 per other trial role, 2 per oral or late-breaking talk and 0.5 per poster in our verified 2026 meeting rows, each halved every 24 months. Paper authorship is not scored yet. PubMed counts are author name plus indication, for the top 12; names are as the registry spells them, so a common name can pool several people. Open a row for their trials and links to their papers.
Maryam FouladiNationwide Children's Hospitalscore 4.4
Score 4.4 = 4.4 leading Phase 2+ trials + 0.1 other trial roles + 0 talks + 0 posters. 3 of 4 trials are Phase 2+.
- Ph2NCT06161974 · Rigel Pharmaceuticals · Study of Olutasidenib and Temozolomide in HGG
- Ph2NCT05096481 · Nationwide Children's Hospital · PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
- Ph2NCT05843253 · Nationwide Children's Hospital · Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
- Ph1NCT03605550 · Nationwide Children's Hospital · A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Eric M ThompsonWashington University School of Medicinescore 4.3
Score 4.3 = 4.3 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 2 of 2 trials are Phase 2+.
- Ph1/Ph2NCT06639607 · Washington University School of Medicine · PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma
- Ph2NCT05096481 · Nationwide Children's Hospital · PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
Tom DavidsonChildren's Hospital Los Angelesscore 3
Score 3 = 3 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Giselle Saulnier ShollerPenn State Health Children's Hospitalscore 2.5
Score 2.5 = 2.5 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Yuanyuan ChenSun Yat-Sen University Cancer Centerscore 2.5
Score 2.5 = 2.5 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Margot LazowNationwide Children's Hospitalscore 2.2
Score 2.2 = 2.1 leading Phase 2+ trials + 0.1 other trial roles + 0 talks + 0 posters. 2 of 3 trials are Phase 2+.
- Ph1/Ph2NCT05278208 · Nationwide Children's Hospital · Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
- Ph2NCT05843253 · Nationwide Children's Hospital · Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
- Ph1NCT03605550 · Nationwide Children's Hospital · A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
David S. ZieglerSydney Children's Hospitals Networkscore 1.9
Score 1.9 = 1.9 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Peter de BlankChildren's Hospital Medical Center, Cincinnatiscore 1.9
Score 1.9 = 1.9 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Sara KhanNationwide Children's Hospitalscore 1.9
Score 1.9 = 1.9 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Heather McCreaUniversity of Miamiscore 1.8
Score 1.8 = 1.8 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Michael J FisherChildren's Hospital of Philadelphiascore 1.6
Score 1.6 = 1.6 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Nicholas G GottardoPerth Children's Hospitalscore 1.6
Score 1.6 = 1.6 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Santosh ValviPerth Children's Hospitalscore 1.6–
Score 1.6 = 1.6 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Daniel LandiDuke Cancer Centerscore 1.3–
Score 1.3 = 1.3 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
John LigonUniversity of Floridascore 1–
Score 1 = 0 leading Phase 2+ trials + 1 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Luca SzalontayChildren's National Research Institutescore 1–
Score 1 = 0 leading Phase 2+ trials + 1 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Lung-Ji ChangShenzhen Geno-Immune Medical Institutescore 1–
Score 1 = 0 leading Phase 2+ trials + 1 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Cori AbikoffBrainChild Bio, Incscore 0.9–
Score 0.9 = 0 leading Phase 2+ trials + 0.9 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Josh NemanNeOnc Technologies Holdings, Inc.score 0.9–
Score 0.9 = 0 leading Phase 2+ trials + 0.9 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Thomas ChenNeOnc Technologies Holdings, Inc.score 0.9–
Score 0.9 = 0 leading Phase 2+ trials + 0.9 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Sabine MuellerUniversity of California, San Franciscoscore 0.8–
Score 0.8 = 0.5 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 1 of 2 trials are Phase 2+.
- Ph1NCT05478837 · University of California, San Francisco · Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma
- Ph2NCT05009992 · University of California, San Francisco · Combination Therapy for the Treatment of Diffuse Midline Gliomas
Gregory Kane Friedman FriedmanM.D. Anderson Cancer Centerscore 0.8–
Score 0.8 = 0 leading Phase 2+ trials + 0.8 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Jacques GRILLGustave Roussy, Cancer Campus, Grand Parisscore 0.7–
Score 0.7 = 0.7 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Brandon ImberMemorial Sloan Kettering Cancer Centerscore 0.7–
Score 0.7 = 0 leading Phase 2+ trials + 0.7 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Adam L GreenChildren's Oncology Groupscore 0.6–
Score 0.6 = 0.6 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
David S ZieglerPediatric Early Phase Clinical Trial Networkscore 0.6–
Score 0.6 = 0.6 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Erin K BarrPediatric Early Phase Clinical Trial Networkscore 0.6–
Score 0.6 = 0 leading Phase 2+ trials + 0.6 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Stephanie M YoonCity of Hope Comprehensive Cancer Center LAOscore 0.6–
Score 0.6 = 0 leading Phase 2+ trials + 0.6 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Tobey MacDonaldEmory Universityscore 0.6–
Score 0.6 = 0 leading Phase 2+ trials + 0.6 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Roman O. KowalchukMayo Clinic in Rochesterscore 0.5–
Score 0.5 = 0.5 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Zwi N BernemanAntwerp University Hospital, Division of Hematology and Center for Cell Therapy and Regenerative Medicinescore 0.5–
Score 0.5 = 0.5 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Rebecca RonsleySeattle Children's Hospitalscore 0.4–
Score 0.4 = 0 leading Phase 2+ trials + 0.4 other trial roles + 0 talks + 0 posters. 0 of 2 trials are Phase 2+.
- Ph1NCT05768880 · Seattle Children's Hospital · Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
- Ph1NCT04185038 · Seattle Children's Hospital · Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
Theodore S JohnsonAugusta Universityscore 0.3–
Score 0.3 = 0.3 leading Phase 2+ trials + 0 other trial roles + 0 talks + 0 posters. 1 of 1 trials are Phase 2+.
Christopher DeRenzoSt. Jude Children's Research Hospitalscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Giedre KrenciuteSt. Jude Children's Research Hospitalscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Hideho OkadaUniversity of California, San Franciscoscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Kelsey BertrandSt. Jude Children's Research Hospitalscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Michael PlattenGerman Cancer Research Center Germanyscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Sadhana JacksonNational Cancer Institute (NCI)score 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.
Stergios ZacharoulisColumbia Universityscore 0.3–
Score 0.3 = 0 leading Phase 2+ trials + 0.3 other trial roles + 0 talks + 0 posters. 0 of 1 trials are Phase 2+.